Genetic approaches have implicated Nox/Duox-derived ROS in biological roles and pathological conditions, including hypertension (Nox1), innate immunity (Nox2, Duox), suppression of pathogen-induced cell death (plant Nox), stomatal closure (plant Nox), otoconia formation in the inner ear (Nox3), biosynthesis of extracellular matrix (Duox), and thyroid hormone biosynthesis (Duox1/2) [18,24,29,43-48]. This evidence concerns the gene DUOX1 and hypertensive disorder.