For instance, one member of this group of genes, osm-12, is the C. elegans homolog of a human disease gene, BBS7. Bardet-Biedle syndrome (BBS; OMIM 209900) is a rare, pleiotropic disorder with multiple pathologies (obesity, rod-cone dystrophy, cognitive impairment) [60]. Here, BBS7 is linked to obesity due to melanocortin 4 receptor deficiency.