LPL and familial lipoprotein lipase deficiency: Consistent with the Kit-induced hepatic phenotype, interference with lipase function induces type I hyperlipoproteinemia in human (OMIN238600) and more severe hyperchylomicronemia affecting post-natal viability in Lpl mutant mice [37] or in Combined Lipase deficiency (Cld), which alters both Lpl and Hepatic lipase (Lipc) activities [38-40].