A previous report indicated that modulating COX-2 protein expression with a structural analog of celecoxib (sc-236) or with the pharmacologic COX-2 protein-suppressing agent curcumin affected apoptosis in the COX-2-positive colon cancer cell line HT-29 [49]; another report showed that modulating COX-2 protein expression with the retinoid X receptor-selective retinoid LGD1069 decreased PGE2 production in normal human mammary epithelial cells [50]. The gene discussed is PTGS2; the disease is colonic neoplasm.