First clinical experience indicates that LCL-stimulated T cell lines may cause tumor regression in some cases but clinical responses are often partial and transient [21], most likely because of immune evasion strategies by tumor cells such as non-expression of the EBNA3 family of proteins, the immunodominant targets of the latent antigen-specific CD8+ T cell response [3], [8]. The gene discussed is CD8A; the disease is neoplasm.