However, neither the bioactivity of IL-18 nor the influence of IFN-γ on inflammatory processes in the peripheral blood mononuclear cells (PBMC) from psoriatic scales could be detected [12].The level of IL-18 mRNA was demonstrated to be 2- to 8-fold higherin extracts from psoriatic skin lesions than the one obtained fromboth uninvolved skin extracts in psoriasis patients and healthysubjects. The gene discussed is IL18; the disease is psoriasis.