Among the natural anticoagulants, protein S deficiency was a significant marker with 21.88% of the patients showing his deficiency (RR 4.6; 95% CI 2.6 – 5.6 P < 0.05) while Protein C deficiency was found to in one case (3.13%; RR 2.8 ; 95% CI 0.5–4.1 P NS). The gene discussed is PROS1; the disease is hyperinsulinemic hypoglycemia, familial, 4.