Membrane-type 1 expression by cells of orthotopically implanted human ovarian cancer biopsies has been linked to a more aggressive tumorigenicity (Drew et al, 2004), and inhibition of MT1 activity has been shown to block collagen invasion in one ovarian cancer cell line, DOV-13 (Ellerbroek et al, 1999; Ellerbroek et al, 2001). This evidence concerns the gene MT1F and ovarian cancer.