Consistent with these observations, MT1 overexpression in some cancer cell types appears to promote motility on collagen I and fibronectin matrices, although the requirement for its enzymatic activity in this process is controversial (Giannelli and Antonaci, 2000; Kajita et al, 2001; Endo et al, 2003; Hornebeck and Maquart, 2003; Koshikawa et al, 2005; cf. Cao et al, 2004). The gene discussed is MT1F; the disease is cancer.