In contrast, we did not observe an association between MVD and HER2 status (median microvessel counts for HER2-positive and HER2-negative tumours of 8 and 7, respectively, P=0.5), nodal status (expressed as either the nodal ratio (P=0.8), or the absolute number of positive nodes (P=0.4)), p53 status (P=0.9), or histologic grade (P=0.8). Here, TP53 is linked to neoplasm.