Also, VEGF induction has been reported in acute myeloid leukemia patients following treatment with sunitinib [26], and induction of VEGF and PlGF has been observed in patients with AML or myelodysplastic syndrome following treatment with the VEGFR inhibitor AG-013736 [33], implying that induction of VEGFR ligands is not limited to patients with solid tumors. This evidence concerns the gene PGF and acute myeloid leukemia.