CD4 and Splenomegaly: Patients with ALPS have chronic, nonmalignant lymphadenopathy and splenomegaly of childhood onset and an increased risk of B-cell lymphomas, autoimmune complications, especially autoimmune cytopenias, increased numbers of normally rare α/βTCR CD3+CD4-CD8- or "double negative T cells" (DNTs), and defective lymphocyte apoptosis in vitro [1].