Adenoviral vectors carrying a PTM engineered to bind to intron 9 of the CFTR pre-mRNA and trans-splice exons 10–24 of wild-type CFTR were transfected into either human CF airway epithelial cultures or in bronchial xenografts, resulting in functional correction of chloride transport of 16%–22% [39]. This evidence concerns the gene CFTR and cystic fibrosis.