Inhibition of KCC2 by BUM would be expected to have the opposite effect on touch-evoked responses because decreased KCC2 expression (analogous to pharmacological inhibition) or KCC2 blockade with DIOA reverses the polarity of GABAAR responses in a subset of lamina I and II neurons, leading to allodynia which has been proposed as a mechanism of neuropathic pain [28]. The gene discussed is SLC12A5; the disease is neuropathic pain.