However, it is known that IgG3 responses to malaria antigens are the slowest to develop, with predominance of IgG3 over IgG1 to MSP-2, an antigen that preferentially induces IgG3 responses, not being fully established until late adolescence, and IgG1 being the predominant response in very young children (<2 yrs-age) [25,26]. Here, IGHG3 is linked to malaria.