CISH and Familial prostate cancer: Of the 30 genes, six (CISH, KIAA0182, ICA1, PGR, SLC1A4, XBP1) were up-regulated by estrogen signaling (in cluster "B" from ref 13) and six (KIAA0182, GLUD1, FOXA1, FXYD3, NPDC1, HIST2H2BE) were up-regulated (p<0.001) by androgen signaling, based on analysis of data from published RNA profiling studies of breast cancer [13] and prostate cancer [14] cell cultures, respectively.