HIF1A and neoplasm: However, we were not able to show an association between the vascularisation or tumor perfusion seen in CDS images and glucose metabolism as shown by FDG PET parameters, reflecting the problem of adverse effects such as flow based supply of oxygen and glucose, p53 gene based stimulation of tumor angiogenesis and glucose metabolism as well as hypoxia induced HIF-1α expression of glucose transport proteins and hexokinase.