CD4 and neoplasm: In previous studies, the tumorigenicity in A/J mice of Neuro-2A cells transfected with IL-2 and IL-12 (Neuro-IL2/IL12) was abolished, and Neuro-IL2/IL12 cells injected into established tumours generated an anti-neuroblastoma immune response, involving both CD8+ and CD4+ T cells, that led to tumour eradication in some mice (Siapati et al, 2003).