A recent report demonstrates that this pathway can be targeted and successfully inhibited in other disease using a humanised monoclonal antibody that targets the IL-6 receptor (in a similar to which herceptin targets HER2 (Jia et al, 2004; Nakahara and Nishimoto, 2006; Nishimoto and Kishimoto, 2006) and this approach has proved successful in prostate cancer animal models (Wallner et al, 2006). Here, ERBB2 is linked to prostate carcinoma.