IL1B and periodontal disorder: Potential mechanisms that were put forward to explain the relationship between periodontal disease (PD) and PTLBW infant delivery was that periodontal infection serves as a chronic reservoir of lipopolysaccharide (LPS) which are responsible for the production of interleukin-1beta (IL-1β), prostaglandin E2 (PGE2), and tumour necrosis factor-alpha (TFNα) that are in turn associated with preterm parturition and fetotoxicity [10,14].