Based on the coexistence of the transcriptional upregulation of Trp53 and Ink4a/Arf deletion in the p53 pathway, the deregulated cell cycle progression, and the scattered pattern of alterations in the apoptosis pathways, etc., both tumor suppressor mechanism and apoptosis pathway seemed to be shattered into discrete pieces in which the coordination between the components no longer existed. The gene discussed is CDKN2A; the disease is neoplasm.