Groups of TRAF2DN/Bcl-2 mice that had developed leukemia were injected i.v. with empty liposomes or with liposomes containing either CDDO (20 mg/Kg) or CDDO-Im, at doses of 5, 10 or 20 mg/kg/day (Table 1 and Figure 3A). This evidence concerns the gene BCL2 and leukemia.