For example, increasing the concentration of FGF2 protein appears to offset the functional outcome of neonatal damage to the motor cortex (Monfils et al. 2005), and the neuroprotective effect of nicotine in animal models of Parkinson disease (Quik and Di Monte 2001) is associated with its ability to up-regulate fgf2 expression (Belluardo et al. 2004). Here, FGF2 is linked to Parkinson disease.