The non-pancreatic malignancies that were studied as a control group (Table 2) also yielded the data that SMAD4 shows negative immunoreactivity in colonic and pulmonary adenocarcinoma, however in 10% of breast ductal and ovarian mucinous adenocarcinoma, focal low positivity nuclear staining may be observed. The gene discussed is SMAD4; the disease is ovarian mucinous adenocarcinoma.