The role of the non-synonymous coding Endostatin polymorphism (4349G > A) in exon 42 of the Collagen 18A gene in carcinogenesis has been evaluated in several cancers including that of the prostate [17,24,25], large bowel [26], multiple myeloma [18] and leukaemia [27]. The gene discussed is COL18A1; the disease is leukemia.