Assessment of tumor angiogenesis revealed a significant increase in microvessel density in EPOR-R129C tumors compared to vector controls (P = 0.0008, figure 7E) and the increased microvessel density in EPOR-R129C tumors was associated with significant decrease of tumor hypoxia as determined by immunostaining for pimonidazole adduct formation (P = 0.026, figure 7F). Here, EPOR is linked to neoplasm.