SOD2 and Alzheimer disease: The trends we observed, of increased amyloid burden (Figure 4A) and Aß42 (Figure 4C) as a result of sod2 heterozygosity, is consistent with a previous report where amyloid load was increased by approximately 2 fold compared to controls through genetic combination of sod2 heterozygotes with the Tg19959 model of AD [27].