SOD2 and Alzheimer disease: Each of these hyperphosphorylated residues has been previously associated with aggregated hyperphosphorylated tau in AD [32], and in the high-dose treated sod2 null animals, we observed a significant normalization of phosphorylation toward wild-type levels of phosphorylation in 3 out of 4 residues which were hyperphosphorylated (Figure 1).