Recently in a series of 28 advanced colorectal patients treated with gefitinib monotherapy, biologic evaluation of total and activated EGR, activated Akt, MAPK and Ki 67 on paired pre- and 1-week post-treatment tumour samples could not confirm a gefitinib-induced decreased expression of these molecular markers (Rothenberg et al, 2005). Here, AKT1 is linked to neoplasm.