S100A4 promotes angiogenesis and extracellular matrix degradation through its upregulation of specific matrix metalloproteases (reviewed in Helfman et al, 2005) and high levels of S100A4 expression are associated with metastatic progression in a wide range of cancers including medulloblastoma (Hernan et al, 2003). The gene discussed is S100A4; the disease is medulloblastoma.