Additional S100 genes either (i) showed evidence of methylation-dependent regulation in a more limited number of cell lines (<2; S100A3, S100A11, S100P and S100G), and were therefore not investigated further in the present study, or (ii) were not represented on the U133A expression microarray (e.g., S100A15), suggesting that more systematic investigations are now required to investigate any roles for DNA methylation events in the epigenetic regulation of further S100 family members in medulloblastoma. Here, S100A3 is linked to medulloblastoma.