For S100A6 and S100A10, the majority of medulloblastomas were unmethylated (35 out of 40 and 31 out of 35 of analysable samples, 87.5 and 88.5% respectively); however five tumours (12.5%) and seven cell lines (78%) showed evidence of hypermethylation of the S100A6 promoter relative to the normal cerebellum. This evidence concerns the gene S100A10 and neoplasm.