Furthermore, analysis of DNA methylation changes shows that some medulloblastoma cell lines (e.g., MHH-MED1, MEB-MED8A) show both hypermethylation (e.g., of S100A6) and hypomethylation (e.g., of S100A4) of genes in close physical proximity, suggesting that epigenetic remodelling appears to be localised within the S100 cluster, involving gene-specific hypermethylation and hypomethylation events. This evidence concerns the gene S100A4 and medulloblastoma.