S100A6 methylation showed a statistically significant association with the large cell/anaplastic histopathological morpho-phenotype (50%; (3 out of 6) of large cell/anaplastic tumours vs 8% (2 out of 25) of classic and 0% (0 out of 9) of nodular/desmoplastic tumours; P=0.026 by Fisher's exact test). This evidence concerns the gene S100A6 and neoplasm.