S100A2 and medulloblastoma: In view of the methylation-dependent transcriptional silencing associated with a range of S100A2 methylation states in medulloblastoma cell lines (Figure 2A and D), our data suggest that S100A2 methylation in the normal cerebellum is associated with its somatic epigenetic transcriptional silencing, but more detailed investigations are now required to explore any role for the epigenetic deregulation of S100A2 in medulloblastoma.