In glioma cells, the expression of ECM components, such as decorin, tenascin, vitronectin, laminin, fibronectin, type I collagen, type IV collagen, neuronal cell adhesion molecule (NCAM), N-cadherin, and beta-catenin, dramatically changes during tumor progression, and these ECM proteins have been reported to play a significant role in the migration and invasion of gliomas [18,20-29]. Here, NCAM1 is linked to central nervous system cancer.