For example, HDAC1 stimulates angiogenesis in epithelial cells (Kim et al., 2001), an event associated with retinal disease and other age-associated pathologies (Gariano & Gardner, 2005), and generates hepatic steatosis in mice (Wang et al., 2005), a pathological condition associated with increased age, body weight, and fibrosis (Perumalswami et al., 2006). Here, HDAC1 is linked to Hepatic steatosis.