EP300 and melanoma: Additional data supporting the role of chromatin remodeling in senescence of melanocytes include evidence that changes in p300 HDAC activity by overexpression of a dominant negative p300 protein or treatment with Lys-CoA (a specific chemical inhibitor of p300 HAT) result in early senescence of normal melanocytes, and surprisingly, also of melanoma cells (Bandyopadhyay et al., 2002).