CCND1 and esophageal adenocarcinoma: A report from a prospective case-control (phase 4) study said that individuals with the CCND1 A/A genotype were at increased risk for gerd, Barrett esophagus, and esophageal adenocarcinoma, supporting the hypothesis that this polymorphism is an individual susceptibility factor in the molecular progression of esophageal adenocarcinoma 115.