Fernandez et al. showed that patients in the acute period of HUS have monocytes with phenotypic (reduced expression of CD14, CD64, and CD11b) and functional [decreases lipopolysaccharide (LPS)-induced TNF-α production and Fcγ-dependent cytotoxicity] differences compared with healthy children and acute uremic children [27]. The gene discussed is ITGAM; the disease is hemolytic-uremic syndrome.