In order to elucidate the role of NF-κB in prion infection, we addressed the question whether NF-κB activity is altered after acute infection with the pathological prion protein in a neuroblastoma cell line (Bos2 cells) (Bosque and Prusiner, 2000), and in the mouse model of prion infection. Here, NFKB1 is linked to neuroblastoma.