All the MOG variants including full-length (MOG 25.1/25.6, MOG 20.5, MOG 20.2, MOG 22.2/22.7, MOG 16.3 alpha 4 and MOG 16.3 beta 4) were detectable in brain tissue (normal appearing white matter) samples from individuals with multiple sclerosis (Fig. 6b). Here, MOG is linked to multiple sclerosis.