One-year changes from baseline values were associated with stroke risk in multivariate analysis for only one biomarker: von Willebrand factor (lowest quintile of change OR 0.66, 95% CI 0.35–1.23; middle quintile, including no change, referent; highest quintile OR 0.95, 95% CI 0.51–1.74; p = 0.04). The gene discussed is VWF; the disease is Stroke.