In light of a recent report by Schumm et al, demonstrating the critical role of p52/p100 NF-κB subunit in p53-dependent p21 regulation in U-2 0S cells [32], it was of interest to investigate the role of p53 in TNF-α-induced p21 in glioma cells. The gene discussed is NFKB1; the disease is glioma.