ILF3 and viral infectious disease: NF90 belongs to a family of double-stranded-RNA binding proteins [32], which has been reported to regulate replication of the Pestivirus BVDV [33] (phylogenetically related to the Flavivirus family to which HCV belongs) and when introduced into osteosarcoma cell line it induces resistance to HIV replication in cell culture [34] acting as a component of cell defense against viral infection by activation of some IFN-response genes [34].