CCR5 and chronic hepatitis C virus infection: In addition, it has been reported [18], that RANTES/CCR5 expression is important in regulating relevant pathological events in the course of chronic hepatitis C infection; as well, intrahepatic expression of RANTES is positively related to the severity of hepatic inflammation in chronic hepatitis C. These results highlighted the significant role of this chemokine in HCV-induced liver disease.