HepG2 cell line, a human hepatoblastoma cell line with hepatocytes characteristics, has been extensively investigated for the mechanisms of hepatocarcinogenesis; with regard to RANTES secretion HepG2 cell line behaves as tumor cells, whereas Chang Liver cells, a fibroblast-like cell line that is immortalized but without tumor phenotype, behave as non tumor cells with regard to the RANTES expression. Here, CCL5 is linked to hepatoblastoma.