As secreted soluble molecules can promote tumour-derived immunosuppression, we examined the expression of two isoforms of TGFβ, which can be produced by melanoma cells and by suppressor or regulatory lymphocytes; IL-10, produced by DCs and suppressive or regulatory T lymphocytes and IDO, produced mainly by APC of myeloid origin. This evidence concerns the gene TGFB1 and neoplasm.