Data on the influence of TGFβ2 on APC are scarce, but this cytokine has been shown to inhibit the antigen presenting abilities of epidermal APC in mice (Hosoi et al, 1993), and its presence correlated with tumour progression, despite peripheral antitumour T-cell activity in glioblastoma patients (Liau et al, 2005). The gene discussed is TGFB2; the disease is neoplasm.