In schistosome infections which drive dominant type-2 responsiveness, however, only a small proportion of the IL-10 emanates from CD25+Foxp3+ T cells 51, 52, and even though IL-10 is important in the overall control of immune pathology in schistosomiasis, granuloma modulation is IL-10-independent 8. This evidence concerns the gene IL2RA and schistosomiasis.