The emphasis on the role of both insulin and insulin-like growth factors 1 (IGF-1) or IGF binding proteins (IGFBPs), together with the insulin-mediated regulation of fat distribution, availability of sex hormone binding globulin (SHBG), and sex hormones in the regulation of proliferation and growth of breast derived cells, has undermined the relevance of glucose by itself in breast cancer [2-5]. Here, SHBG is linked to breast cancer.