TXNIP and neoplasm: Even though the incompleteness of this exploratory work that was meant to validate the preliminary findings of increased level of TXNIP observed in GEP in response to hyperglycemia hampers the understanding of the ultimate consequence of increased ROS for the growth of tumor cells in the metabolic conditions of hyperglycemia, we are confident that further investigative work will lead to the identification of the molecular mechanisms relating diabetes to cancer.