First-degree family histories of breast cancer (OR = 2.65, 95% CI = 1.15 to 6.09) or of breast and/or ovarian cancer (OR = 3.15, 95% CI = 1.44 to 6.91) were both significantly associated with ESR1 A908G mutation positivity (not shown). This evidence concerns the gene ESR1 and breast carcinoma.