While increased IL-16 has been reported in local lesions of chronic immune diseases, including allergen-induced bronchial asthma and rheumatoid arthritis [34] and in the mucosa of patients with inflammatory bowel disease, including ulcerative colitis and Crohn's disease [35], [36], the systemic role of IL-16 is a new finding. This evidence concerns the gene IL16 and rheumatoid arthritis.