FAS and colonic neoplasm: Reasons proposed for the decreased FAS sensitivity of colon tumour cell lines include downregulation of FAS receptor expression (von Reyher et al, 1998), overexpression of Bcl-2 (O'Connell et al, 2000) or FLICE-inhibitory protein (Ryu et al, 2001) and mutation of p53 (Tamura et al, 1995).