FAS and adenocarcinoma: FAS is highly expressed in normal human colonic epithelial cell and its expression is progressively decreased during tumour progression from normal epithelium to adenocarcinoma in about 50% of the cases (Leithauser et al, 1993; Moller et al, 1994), whereas FASL has been shown to be upregulated early during colon carcinogenesis (Bennett et al, 2001).