In comparison, there is a marked increase in sensitivity to TRAIL-induced apoptosis associated with progression from benign to malignant tumour with the assumption that the sensitivity to TRAIL is acquired early in colorectal tumorigenesis during the formation of the adenoma (Strater et al, 2002; Koornstra et al, 2003; Daniels et al, 2005; Hague et al, 2005). This evidence concerns the gene TNFSF10 and adenoma.