Even though a number of studies tested TRAIL in vivo for its ability to induce apoptosis in tumour xenografts, none ever reported on the DR status or alterations in the cell lines before and while in SCID mice (Gliniak and Le, 1999; Walczak et al, 1999; Kelley et al, 2001; Naka et al, 2002; Finnberg et al, 2005; Hylander et al, 2005). The gene discussed is TNFSF10; the disease is neoplasm.