TNFRSF25 and systemic lupus erythematosus: When analysis was limited to males who had SLE-associated HLA genes (encoding DR2 or DR3), there was an even greater increase in identity between SLE patients and their mothers in DRB1 families and DRB1 variant alleles (OR 7.2, p = 0.01 and OR 15, p = 0.018).