VEGFR2 tyrosine phosphorylation was reported to be enhanced by VEGF in breast cancer and to lead to increased ERK1/2 (extracellular signal-regulated kinase 1/2) and AKT phosphorylation, suggesting that VEGF stimulation is important in the regulation of cell growth, apoptosis, and differentiation [31]. This evidence concerns the gene VEGFA and breast carcinoma.