Since gliomas harboring p53 mutations and immuno-positive for p53 (G2, G7, and G8) as well as gliomas harboring wild type p53 and immuno-negative for p53 (G4 and G10) expressed MGMT mRNA (Figure 5, Table 2), MGMT might be regulated primarily by the factors other than p53 in gliomas. The gene discussed is MGMT; the disease is central nervous system cancer.