TP53 and central nervous system cancer: Since gliomas harboring p53 mutations and immuno-positive for p53 (G2, G7, and G8) as well as gliomas harboring wild type p53 and immuno-negative for p53 (G4 and G10) expressed MGMT mRNA (Figure 5, Table 2), MGMT might be regulated primarily by the factors other than p53 in gliomas.