CRHR1 and obesity due to melanocortin 4 receptor deficiency: It could be concluded that such high frequency may be produced by the lack of gallbladder motility due to the lack of CCK-1R plus hyperlipidemia due to obesity, although the difference in frequency between CCK-1R(-/-) mice fed CRF-1 (3 of 8 mice) and those fed OA-2 did not quite show statistical significance (p = 0.093).