This has been shown in normal liver and intense reactivity occurs on endothelial cells in heptacellular carcinomas.38, 49 In addition, syndecan-3 has recently been shown in the blood vessels of non-malignant ovarian tissues with intense reactivity occurring on blood vessels in ovarian cancer.50 In the RA synovium, out of the syndecans and glypicans tested, syndecan-3 was the most abundantly detected HSPG in endothelial cells. This evidence concerns the gene GPC1 and ovarian cancer.