Recently, it has been shown that phagocytosis of P. falciparum haemozoin (HZ) and synthetic HZ (sHZ, beta-haematin) by murine phagocytes significantly increased IFN-gamma-mediated iNOS expression and NO production [14], offering a mechanistic link to the increased, possibly protective NO levels observed in clinical malaria. Here, NOS2 is linked to malaria.