Various risk factors have been pointed out for MBC, including BRCA2 gene anomalies [10], Klinefelter's syndrome [11], a genetic background such as a familial history of breast cancer, hormonal abnormalities due to obesity or testicular disease (cryptorchidism, mumps, orchitis, orchiectomy), exposure to radiation [1-4]. Here, BRCA2 is linked to obesity due to melanocortin 4 receptor deficiency.